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Institut za biološka istraživanja „Siniša Stanković”
Institut od nacionalnog značaja za Republiku Srbiju
Univerzitet u Beogradu

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Changes in Soil Properties Under the Influence of Microplastics in Plastic and Open Field Production in Three Serbian Valleys

Crop production in plastic greenhouses is one of the major sources of plastic pollution worldwide. The main hypothesis of this study is that the regular use of mulch film in greenhouses leads to the cumulative accumulation of microplastic particles (MPs) in the soil, which ultimately leads to changes in the soil properties. Therefore, the main objective of this study was to identify the possible changes in the physical, chemical, and biological properties of soil in greenhouses in three regions of Serbia...

The effect of different cytokinins on in vitro shoot culture of an endemic and endangered Gentianella lutescens subsp. carpatica (Beck) Holub

Gentianella lutescens subsp. carpatica (Beck) Holub, a rich source of xanthones with specific bioactive properties, is limited in nature. To improve shoot proliferation and growth, shoot explants were cultured for five weeks in vitro on Murashige and Skoog medium enriched with individual cytokinins: N6-benzyladenine (6-BA), kinetin (KIN), meta-topolin (mT), thidiazuron (TDZ) and forchlorfenuron (CPPU), (concentrations range 0–15 µM)...

Exploring SAR insights into royleanones for P-gp modulation

Multidrug resistance (MDR) poses a challenge in contemporary pharmacotherapy, significantly reducing the efficacy of chemotherapeutic agents. Among the array of mechanisms underpinning MDR, the upregulation of P-glycoprotein (P-gp), also known as MDR1 and encoded by the ABCB1 gene, emerges as an impediment in cancer treatment success. Plants from the Plectranthus genus (Lamiaceae) are recognised in traditional medicine for their diverse therapeutic applications. 7α-acetoxy-6β-hydroxyroyleanone (Roy), the principal diterpene derived...

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